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Science Nature News
GTP release-selective agonists prolong opioid analgesic efficacy

Nature, Published online: 17 December 2025; doi:10.1038/s41586-025-09880-5Mu opioid receptor agonists with a preference for the non-GTP-bound state of the G protein promote GTP release, thereby …

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Gene-specific selective sweeps are pervasive across human gut microbiomes

Nature, Published online: 17 December 2025; doi:10.1038/s41586-025-09798-yDevelopment and application of the integrated linkage disequilibrium score (iLDS) reveals both selective pressures impacting the human gut microbiome …

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Transient hepatic reconstitution of trophic factors enhances aged immunity

Nature, Published online: 17 December 2025; doi:10.1038/s41586-025-09873-4Using lipid nanoparticle delivery of mRNAs to the liver in aged mice, T cell function and declining immune cues …

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Is bird flu the next pandemic? The science so far

Nature, Published online: 17 December 2025; doi:10.1038/d41586-025-03777-zKey mutations and animal spread could raise the risk to humans.

Science Nature News
Biobanks reveal genetic complexity in human evolution

Nature, Published online: 17 December 2025; doi:10.1038/d41586-025-04079-0Tiny genetic variations between humans, Neanderthals and Denisovans might not be all they were cracked up to be.

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How the Romans built their empire of concrete

Nature, Published online: 17 December 2025; doi:10.1038/d41586-025-04080-7A unique archaeological site at Pompeii, Italy, reveals the secrets of peculiarly durable Roman building materials.

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Author Correction: Neuroimmune cardiovascular interfaces control atherosclerosis

Nature, Published online: 17 December 2025; doi:10.1038/s41586-025-10043-9Author Correction: Neuroimmune cardiovascular interfaces control atherosclerosis

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Mazdutide versus placebo in Chinese adults with type 2 diabetes

Nature, Published online: 17 December 2025; doi:10.1038/s41586-025-10026-wMazdutide versus placebo in Chinese adults with type 2 diabetes

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Mazdutide versus dulaglutide in Chinese adults with type 2 diabetes

Nature, Published online: 17 December 2025; doi:10.1038/s41586-025-10031-zMazdutide versus dulaglutide in Chinese adults with type 2 diabetes

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AI is transforming the economy — understanding its impact requires both data …

Nature, Published online: 16 December 2025; doi:10.1038/d41586-025-04053-wControlled studies capture only a fraction of the effects of artificial intelligence. Economists should work with social scientists to …

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How my institution strengthened research despite chronic underfunding

Nature, Published online: 16 December 2025; doi:10.1038/d41586-025-04050-zNurturing research talent at community-rooted universities and colleges is a necessity, not a luxury.

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Scientists skip key US meetings — and seize on smaller alternatives

Nature, Published online: 16 December 2025; doi:10.1038/d41586-025-04083-4Researchers are devising creative ways to get together as Trump’s policies curb travel to US gatherings.

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Science’s role in my <i>Great British Sewing Bee</i> success

Nature, Published online: 16 December 2025; doi:10.1038/d41586-025-03536-0A research background and a passion for sewing inspired by her father helped Yasmin Proctor-Kent to reach the finals …

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Safety regulations for cloning and a compass that finds true north

Nature, Published online: 16 December 2025; doi:10.1038/d41586-025-03740-yScientists discuss concerns that genetic manipulation could lead to disease outbreaks, and Nature is gifted an unusual scientific instrument, …

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More than half of researchers now use AI for peer review — …

Nature, Published online: 15 December 2025; doi:10.1038/d41586-025-04066-5A survey of 1,600 academics found that more than 50% have used artificial-intelligence tools while peer reviewing manuscripts.

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Tracing pollution in the lives of Arctic seabirds

Nature, Published online: 15 December 2025; doi:10.1038/d41586-025-03078-5Olivier Chastel travels to Svalbard in northern Norway to study the impact of contaminants such as mercury on black-legged …

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Grant cuts, arrests, lay-offs: Trump made 2025 a tumultuous year for science

Nature, Published online: 15 December 2025; doi:10.1038/d41586-025-04051-yHow the Trump administration caused seismic disruptions to the world’s premier scientific superpower.

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<b>How 2025 showcased the power and resilience of science</b>

Nature, Published online: 15 December 2025; doi:10.1038/d41586-025-04049-6There were huge disruptions to the global scientific enterprise this year — but immense bright spots for health, discovery, …

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The best science images of 2025 — <i>Nature</i>’s picks

Nature, Published online: 15 December 2025; doi:10.1038/d41586-025-03935-3The Sun’s fiery surface, a tattooed tardigrade, rare red lightning and more.

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NSF softens grant-review rules to cope with backlog

Nature, Published online: 15 December 2025; doi:10.1038/d41586-025-04067-4Agency staff members say that the changes are reasonable, but they are worried about the potential effects on review.

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How fasting boosts breast cancer therapy

Nature, Published online: 15 December 2025; doi:10.1038/d41586-025-03809-8A discovery in mice reveals why fasting enhances a type of breast cancer treatment — a hormone-signalling pathway and …

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Giving a voice to animals: Laos’s national herpetologist on her day-to-day

Nature, Published online: 15 December 2025; doi:10.1038/d41586-025-04054-9Somphouthone Phimmachak studies amphibians and reptiles as one of the country’s few conservation researchers.

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Science sleuths raise concerns about scores of bioengineering papers

Nature, Published online: 12 December 2025; doi:10.1038/d41586-025-03870-3Prominent bioengineer Ali Khademhosseini has so far corrected more than 40 of the papers in question, but critics say …

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In praise of inefficiency, failure and friendship: ten galvanizing reads for this …

Nature, Published online: 12 December 2025; doi:10.1038/d41586-025-04052-xIn a world that can seem lacking in optimism, researchers share their opinions on books that stimulate thoughts — …

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